Narcotic Tolerance and Dependence and Serotonin Turnover
نویسندگان
چکیده
منابع مشابه
Narcotic tolerance and dependence and serotonin turnover.
stimuli. Access to and copulation with the females was accompanied by becoming the alpha, or dominant, male in a new group. It is possible that the latter experience isa provocative stimulus to increased testosterone secretion, along with frequent sexual activity. Studies are needed to clarify this issue. With more indirect techniques of assessing testosterone secretion, such as measurement of ...
متن کاملNarcotic Tolerance and Dependence and Serotonin Turnover
stimuli. Access to and copulation with the females was accompanied by becoming the alpha, or dominant, male in a new group. It is possible that the latter experience isa provocative stimulus to increased testosterone secretion, along with frequent sexual activity. Studies are needed to clarify this issue. With more indirect techniques of assessing testosterone secretion, such as measurement of ...
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Narcotics affect adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in two opposing ways, both mediated by the opiate receptor. The first process is the readily reversible inhibition of the enzyme by narcotics; the second is a compensatory increase in enzyme activity which is delayed in onset and relatively stable. Late positive regulation of the enzyme counteracts the inhibito...
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Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were investigated in mice. Materials and Methods: Male adult NMRI mice were made tolerant and dependent by repeated injections of morphine (50, 50, and 7...
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Comparison of C.S. F. H. V. A and 5-HIAA levels of 20 Schizophrenics and 9 non-schizophrenic controls revealed no statistically significant difference between HVA levels but the 5-HIAA levels were significantly less in Schizophrenics (p < 0.05) than in controls. The significance of these findings is discussed.
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ژورنال
عنوان ژورنال: Science
سال: 1972
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.178.4061.645